Clinicians’ use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC risk assessment tools and respondents’ perceived importance of BC risk factors. Respondents (N = 443) varied in age, country and clinical seniority but comprised mainly genetics health professionals (82%) and BWA users (93%). Oncology professionals perceived reproductive, hormonal (exogenous) and lifestyle BC risk factors as more important in BC risk assessment compared to genetics professionals (p values < 0.05 to 0.0001). BWA was used more frequently by respondents who gave high weight to breast tumour pathology and low weight to personal BC history as BC risk factors. BWA use was positively related to the weight given to hormonal BC risk factors. The importance attributed to lifestyle and BMI BC risk factors was not associated with the use of BWA or any of the other tools. Next version of the BWA encompassing additional BC risk factors will facilitate more comprehensive BC risk assessment in genetics and oncology practice.

Detaljer

Författare
  • Anne Brédart
  • Jean Luc Kop
  • Antonis C. Antoniou
  • Alex P. Cunningham
  • Antoine de Pauw
  • Marc Tischkowitz
  • Hans Ehrencrona
  • Marjanka K. Schmidt
  • Sylvie Dolbeault
  • Kerstin Rhiem
  • Douglas F. Easton
  • Peter Devilee
  • Dominique Stoppa-Lyonnet
  • Rita Schmutlzer
Enheter & grupper
Externa organisationer
  • Curie Institute, Paris
  • Paris Descartes University
  • University of Lorraine
  • University of Cambridge
  • Netherlands Cancer Institute
  • University of Paris-Sud
  • University Hospital of Cologne
  • Leiden University Medical Centre
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)61-71
TidskriftJournal of Community Genetics
Volym10
Utgivningsnummer1
Tidigt onlinedatum2018 mar 5
StatusPublished - 2019 jan
PublikationskategoriForskning
Peer review utfördJa