Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens

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Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens. / Bober, Marta; Enochsson, Charlotte; Collin, Mattias; Mörgelin, Matthias.

I: Journal of Innate Immunity, Vol. 2, Nr. 2, 2010, s. 160-166.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Bober, Marta ; Enochsson, Charlotte ; Collin, Mattias ; Mörgelin, Matthias. / Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens. I: Journal of Innate Immunity. 2010 ; Vol. 2, Nr. 2. s. 160-166.

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TY - JOUR

T1 - Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens

AU - Bober, Marta

AU - Enochsson, Charlotte

AU - Collin, Mattias

AU - Mörgelin, Matthias

PY - 2010

Y1 - 2010

N2 - Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel

AB - Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel

KW - Respiratory infection

KW - adhesion

KW - Primary

KW - Host-pathogen interaction

KW - Collagen VI

KW - Adhesin

KW - Airways

KW - Respiratory pathogen

KW - Streptococcus

U2 - 10.1159/000232587

DO - 10.1159/000232587

M3 - Article

VL - 2

SP - 160

EP - 166

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

SN - 1662-811X

IS - 2

ER -