Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats. Interestingly, additional overexpression of neuropeptide Y in the hippocampus strengthened the seizure-suppressant effect of transgene Y2 receptors. Here we show for the first time that another neuropeptide Y receptor, Y5, can also be overexpressed in the hippocampus. However, unlike Y2 receptor overexpression, transgene Y5 receptors in the hippocampus had no effect on kainate-induced motor seizures in rats. However, combined overexpression of Y5 receptors and neuropeptide Y exerted prominent suppression of seizures. This seizure-suppressant effect of combination gene therapy with Y5 receptors and neuropeptide Y was significantly stronger as compared to neuropeptide Y overexpression alone. These results suggest that overexpression of Y5 receptors in combination with neuropeptide Y could be an alternative approach for more effective suppression of hippocampal seizures. (C) 2011 Elsevier Inc. All rights reserved.

Detaljer

Författare
  • Casper R. Gotzsche
  • Litsa Nikitidou
  • Andreas Toft Sörensen
  • Mikkel V. Olesen
  • Gunnar Sorensen
  • Soren H. O. Christiansen
  • Mikael Ängehagen
  • David P. D. Woldbye
  • Merab Kokaia
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)288-296
TidskriftNeurobiology of Disease
Volym45
Utgivningsnummer1
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Nikitidou, L., 2013, Neurology, Lund. 110 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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