Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

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Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. / Stevens, Kristen N.; Vachon, Celine M.; Lee, Adam M.; Slager, Susan; Lesnick, Timothy; Olswold, Curtis; Fasching, Peter A.; Miron, Penelope; Eccles, Diana; Carpenter, Jane E.; Godwin, Andrew K.; Ambrosone, Christine; Winqvist, Robert; Brauch, Hiltrud; Schmidt, Marjanka K.; Cox, Angela; Cross, Simon S.; Sawyer, Elinor; Hartmann, Arndt; Beckmann, Matthias W.; Schulz-Wendtland, Ruediger; Ekici, Arif B.; Tapper, William J.; Gerty, Susan M.; Durcan, Lorraine; Graham, Nikki; Hein, Rebecca; Nickels, Stephan; Flesch-Janys, Dieter; Heinz, Judith; Sinn, Hans-Peter; Konstantopoulou, Irene; Fostira, Florentia; Pectasides, Dimitrios; Dimopoulos, Athanasios M.; Fountzilas, George; Clarke, Christine L.; Balleine, Rosemary; Olson, Janet E.; Fredericksen, Zachary; Diasio, Robert B.; Pathak, Harsh; Ross, Eric; Weaver, JoEllen; Ruediger, Thomas; Försti, Asta; Duennebier, Thomas; Ademuyiwa, Foluso; Kulkarni, Swati; Pylkaes, Katri; Jukkola-Vuorinen, Arja; Ko, Yon-Dschun; Van Limbergen, Erik; Janssen, Hilde; Peto, Julian; Fletcher, Olivia; Giles, Graham G.; Baglietto, Laura; Verhoef, Senno; Tomlinson, Ian; Kosma, Veli-Matti; Beesley, Jonathan; Greco, Dario; Blomqvist, Carl; Irwanto, Astrid; Liu, Jianjun; Blows, Fiona M.; Dawson, Sarah-Jane; Margolin, Sara; Mannermaa, Arto; Martin, Nicholas G.; Montgomery, Grant W.; Lambrechts, Diether; Silva, Isabel dos Santos; Severi, Gianluca; Hamann, Ute; Pharoah, Paul; Easton, Douglas F.; Chang-Claude, Jenny; Yannoukakos, Drakoulis; Nevanlinna, Heli; Wang, Xianshu; Couch, Fergus J.

I: Cancer Research, Vol. 71, Nr. 19, 2011, s. 6240-6249.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Stevens, KN, Vachon, CM, Lee, AM, Slager, S, Lesnick, T, Olswold, C, Fasching, PA, Miron, P, Eccles, D, Carpenter, JE, Godwin, AK, Ambrosone, C, Winqvist, R, Brauch, H, Schmidt, MK, Cox, A, Cross, SS, Sawyer, E, Hartmann, A, Beckmann, MW, Schulz-Wendtland, R, Ekici, AB, Tapper, WJ, Gerty, SM, Durcan, L, Graham, N, Hein, R, Nickels, S, Flesch-Janys, D, Heinz, J, Sinn, H-P, Konstantopoulou, I, Fostira, F, Pectasides, D, Dimopoulos, AM, Fountzilas, G, Clarke, CL, Balleine, R, Olson, JE, Fredericksen, Z, Diasio, RB, Pathak, H, Ross, E, Weaver, J, Ruediger, T, Försti, A, Duennebier, T, Ademuyiwa, F, Kulkarni, S, Pylkaes, K, Jukkola-Vuorinen, A, Ko, Y-D, Van Limbergen, E, Janssen, H, Peto, J, Fletcher, O, Giles, GG, Baglietto, L, Verhoef, S, Tomlinson, I, Kosma, V-M, Beesley, J, Greco, D, Blomqvist, C, Irwanto, A, Liu, J, Blows, FM, Dawson, S-J, Margolin, S, Mannermaa, A, Martin, NG, Montgomery, GW, Lambrechts, D, Silva, IDS, Severi, G, Hamann, U, Pharoah, P, Easton, DF, Chang-Claude, J, Yannoukakos, D, Nevanlinna, H, Wang, X & Couch, FJ 2011, 'Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer', Cancer Research, vol. 71, nr. 19, s. 6240-6249. https://doi.org/10.1158/0008-5472.CAN-11-1266

APA

Stevens, K. N., Vachon, C. M., Lee, A. M., Slager, S., Lesnick, T., Olswold, C., ... Couch, F. J. (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. https://doi.org/10.1158/0008-5472.CAN-11-1266

CBE

Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland R, Ekici AB, Tapper WJ, Gerty SM, Durcan L, Graham N, Hein R, Nickels S, Flesch-Janys D, Heinz J, Sinn H-P, Konstantopoulou I, Fostira F, Pectasides D, Dimopoulos AM, Fountzilas G, Clarke CL, Balleine R, Olson JE, Fredericksen Z, Diasio RB, Pathak H, Ross E, Weaver J, Ruediger T, Försti A, Duennebier T, Ademuyiwa F, Kulkarni S, Pylkaes K, Jukkola-Vuorinen A, Ko Y-D, Van Limbergen E, Janssen H, Peto J, Fletcher O, Giles GG, Baglietto L, Verhoef S, Tomlinson I, Kosma V-M, Beesley J, Greco D, Blomqvist C, Irwanto A, Liu J, Blows FM, Dawson S-J, Margolin S, Mannermaa A, Martin NG, Montgomery GW, Lambrechts D, Silva IDS, Severi G, Hamann U, Pharoah P, Easton DF, Chang-Claude J, Yannoukakos D, Nevanlinna H, Wang X, Couch FJ. 2011. Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research. 71(19):6240-6249. https://doi.org/10.1158/0008-5472.CAN-11-1266

MLA

Vancouver

Author

Stevens, Kristen N. ; Vachon, Celine M. ; Lee, Adam M. ; Slager, Susan ; Lesnick, Timothy ; Olswold, Curtis ; Fasching, Peter A. ; Miron, Penelope ; Eccles, Diana ; Carpenter, Jane E. ; Godwin, Andrew K. ; Ambrosone, Christine ; Winqvist, Robert ; Brauch, Hiltrud ; Schmidt, Marjanka K. ; Cox, Angela ; Cross, Simon S. ; Sawyer, Elinor ; Hartmann, Arndt ; Beckmann, Matthias W. ; Schulz-Wendtland, Ruediger ; Ekici, Arif B. ; Tapper, William J. ; Gerty, Susan M. ; Durcan, Lorraine ; Graham, Nikki ; Hein, Rebecca ; Nickels, Stephan ; Flesch-Janys, Dieter ; Heinz, Judith ; Sinn, Hans-Peter ; Konstantopoulou, Irene ; Fostira, Florentia ; Pectasides, Dimitrios ; Dimopoulos, Athanasios M. ; Fountzilas, George ; Clarke, Christine L. ; Balleine, Rosemary ; Olson, Janet E. ; Fredericksen, Zachary ; Diasio, Robert B. ; Pathak, Harsh ; Ross, Eric ; Weaver, JoEllen ; Ruediger, Thomas ; Försti, Asta ; Duennebier, Thomas ; Ademuyiwa, Foluso ; Kulkarni, Swati ; Pylkaes, Katri ; Jukkola-Vuorinen, Arja ; Ko, Yon-Dschun ; Van Limbergen, Erik ; Janssen, Hilde ; Peto, Julian ; Fletcher, Olivia ; Giles, Graham G. ; Baglietto, Laura ; Verhoef, Senno ; Tomlinson, Ian ; Kosma, Veli-Matti ; Beesley, Jonathan ; Greco, Dario ; Blomqvist, Carl ; Irwanto, Astrid ; Liu, Jianjun ; Blows, Fiona M. ; Dawson, Sarah-Jane ; Margolin, Sara ; Mannermaa, Arto ; Martin, Nicholas G. ; Montgomery, Grant W. ; Lambrechts, Diether ; Silva, Isabel dos Santos ; Severi, Gianluca ; Hamann, Ute ; Pharoah, Paul ; Easton, Douglas F. ; Chang-Claude, Jenny ; Yannoukakos, Drakoulis ; Nevanlinna, Heli ; Wang, Xianshu ; Couch, Fergus J. / Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. I: Cancer Research. 2011 ; Vol. 71, Nr. 19. s. 6240-6249.

RIS

TY - JOUR

T1 - Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

AU - Stevens, Kristen N.

AU - Vachon, Celine M.

AU - Lee, Adam M.

AU - Slager, Susan

AU - Lesnick, Timothy

AU - Olswold, Curtis

AU - Fasching, Peter A.

AU - Miron, Penelope

AU - Eccles, Diana

AU - Carpenter, Jane E.

AU - Godwin, Andrew K.

AU - Ambrosone, Christine

AU - Winqvist, Robert

AU - Brauch, Hiltrud

AU - Schmidt, Marjanka K.

AU - Cox, Angela

AU - Cross, Simon S.

AU - Sawyer, Elinor

AU - Hartmann, Arndt

AU - Beckmann, Matthias W.

AU - Schulz-Wendtland, Ruediger

AU - Ekici, Arif B.

AU - Tapper, William J.

AU - Gerty, Susan M.

AU - Durcan, Lorraine

AU - Graham, Nikki

AU - Hein, Rebecca

AU - Nickels, Stephan

AU - Flesch-Janys, Dieter

AU - Heinz, Judith

AU - Sinn, Hans-Peter

AU - Konstantopoulou, Irene

AU - Fostira, Florentia

AU - Pectasides, Dimitrios

AU - Dimopoulos, Athanasios M.

AU - Fountzilas, George

AU - Clarke, Christine L.

AU - Balleine, Rosemary

AU - Olson, Janet E.

AU - Fredericksen, Zachary

AU - Diasio, Robert B.

AU - Pathak, Harsh

AU - Ross, Eric

AU - Weaver, JoEllen

AU - Ruediger, Thomas

AU - Försti, Asta

AU - Duennebier, Thomas

AU - Ademuyiwa, Foluso

AU - Kulkarni, Swati

AU - Pylkaes, Katri

AU - Jukkola-Vuorinen, Arja

AU - Ko, Yon-Dschun

AU - Van Limbergen, Erik

AU - Janssen, Hilde

AU - Peto, Julian

AU - Fletcher, Olivia

AU - Giles, Graham G.

AU - Baglietto, Laura

AU - Verhoef, Senno

AU - Tomlinson, Ian

AU - Kosma, Veli-Matti

AU - Beesley, Jonathan

AU - Greco, Dario

AU - Blomqvist, Carl

AU - Irwanto, Astrid

AU - Liu, Jianjun

AU - Blows, Fiona M.

AU - Dawson, Sarah-Jane

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Martin, Nicholas G.

AU - Montgomery, Grant W.

AU - Lambrechts, Diether

AU - Silva, Isabel dos Santos

AU - Severi, Gianluca

AU - Hamann, Ute

AU - Pharoah, Paul

AU - Easton, Douglas F.

AU - Chang-Claude, Jenny

AU - Yannoukakos, Drakoulis

AU - Nevanlinna, Heli

AU - Wang, Xianshu

AU - Couch, Fergus J.

PY - 2011

Y1 - 2011

N2 - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.

AB - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.

U2 - 10.1158/0008-5472.CAN-11-1266

DO - 10.1158/0008-5472.CAN-11-1266

M3 - Article

VL - 71

SP - 6240

EP - 6249

JO - Cancer research. Supplement

T2 - Cancer research. Supplement

JF - Cancer research. Supplement

SN - 1538-7445

IS - 19

ER -