Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

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Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavor-able risk factor burden.


  • Anouk L M Eikendal
  • Karlijn A Groenewegen
  • Todd J Anderson
  • Annie R Britton
  • Greg W Evans
  • Jacqueline de Graaf
  • Diederick E Grobbee
  • Suzanne Holewijn
  • Ai Ikeda
  • Kazuo Kitagawa
  • Akihiko Kitamura
  • Eva M Lonn
  • Matthias W Lorenz
  • Ellisiv B Mathiesen
  • Giel Nijpels
  • Jacqueline M Dekker
  • Shuhei Okazaki
  • Daniel H O'Leary
  • Joseph F Polak
  • Jacqueline F Price
  • Christine Robertson
  • Christopher M Rembold
  • Maria Rosvall
  • Tatjana Rundek
  • Jukka T Salonen
  • Matthias Sitzer
  • Coen D A Stehouwer
  • Imo E Hoefer
  • Sanne A E Peters
  • Michiel L Bots
  • Hester M den Ruijter
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Sidor (från-till)707
StatusPublished - 2015
Peer review utfördJa