Common measure of quality of life for people with systemic sclerosis across seven European countries: A cross-sectional study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Objectives the aim of this study was to adapt the Systemic Sclerosis Quality of Life Questionnaire (SScQoL) into six European cultures and validate it as a common measure of quality of life in systemic sclerosis (SSc). Methods this was a seven-country (Germany, France, Italy, Poland, Spain, Sweden and UK) cross-sectional study. A forward–backward translation process was used to adapt the English SScQoL into target languages. SScQoL was completed by patients with SSc, then data were validated against the rasch model. to correct local response dependency, items were grouped into the following subscales: function, emotion, sleep, social and pain and reanalysed for fit to the model, unidimensionality and cross-cultural equivalence. results the adaptation of the SScQoL was seamless in all countries except Germany. Cross-cultural validation included 1080 patients with a mean age 58.0 years (Sd 13.9) and 87% were women. Local dependency was evident in individual country data. Grouping items into testlets corrected the local dependency in most country specific data. Fit to the model, reliability and unidimensionality was achieved in six-country data after cross-cultural adjustment for Italy in the social subscale. the SScQoL was then calibrated into an interval level scale. Conclusion the individual SScQoL items have translated well into five languages and overall, the scale maintained its construct validity, working well as a five-subscale questionnaire. Measures of quality of life in SSc can be directly compared across five countries (France, Poland Spain, Sweden and UK). data from Italy are also comparable with the other five countries although require an adjustment.


  • Mwidimi Ndosi
  • Begonya Alcacer-Pitarch
  • Yannick Allanore
  • Francesco Del Galdo
  • Marc Frerix
  • Sílvia García-Díaz
  • Roger Hesselstrand
  • Christine Kendall
  • Marco Matucci-Cerinic
  • Ulf Mueller-Ladner
  • Gunnel Sandqvist
  • Vicenç Torrente-Segarra
  • Tim Schmeiser
  • Matylda Sierakowska
  • Justyna Sierakowska
  • Stanslaw Sierakowski
  • Anthony Redmond
Enheter & grupper
Externa organisationer
  • University of the West of England
  • University of Leeds
  • Paris Descartes University
  • Justus Liebig University Giessen
  • University of Florence
  • Careggi University Hospital
  • Medical University of Bialystok
  • NHS Foundation Trust
  • NIHR Leeds Biomedical Research Centre
  • Hospital de Sant Joan Despí Moisès Broggi
  • St. Josef Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reumatologi och inflammation
Sidor (från-till)1032-1038
Antal sidor7
TidskriftAnnals of the Rheumatic Diseases
Utgåva nummer7
StatusPublished - 2018
Peer review utfördJa