Comparison of dermal vs internal light administration in human lungs using the TDLAS-GASMAS technique—Phantom studies

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Comparison of dermal vs internal light administration in human lungs using the TDLAS-GASMAS technique—Phantom studies. / Larsson, Jim; Leander, Dennis; Lewander Xu, Märta; Fellman, Vineta; Bood, Joakim; Krite Svanberg, Emilie.

I: Journal of Biophotonics, Vol. 12, Nr. 8, e201800350, 08.2019.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Comparison of dermal vs internal light administration in human lungs using the TDLAS-GASMAS technique—Phantom studies

AU - Larsson, Jim

AU - Leander, Dennis

AU - Lewander Xu, Märta

AU - Fellman, Vineta

AU - Bood, Joakim

AU - Krite Svanberg, Emilie

PY - 2019/8

Y1 - 2019/8

N2 - Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), that is, the TDLAS-GASMAS technique. Oxygen gas is detected through an absorption line near 764 nm and water vapor through an absorption line near 820 nm. A model with a lung containing interior structure is compared to a model with a hollow lung. Compared to the model with the hollow lung, both the mean absorption path length and the transmitted intensity are found to be lower for the model with the structured lung. A new approach, where laser light is delivered internally into the model through an optical fiber, is compared to dermal light administration, that is, illumination onto the skin, for the model with structure inside the lung. The internal light administration generally resulted in larger gas absorption, and higher signal-to-noise ratios, compared to the dermal light administration. The results from the phantom measurements show great promise for the internal illumination approach and a natural next step would be to investigate it further in clinical studies.

AB - Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), that is, the TDLAS-GASMAS technique. Oxygen gas is detected through an absorption line near 764 nm and water vapor through an absorption line near 820 nm. A model with a lung containing interior structure is compared to a model with a hollow lung. Compared to the model with the hollow lung, both the mean absorption path length and the transmitted intensity are found to be lower for the model with the structured lung. A new approach, where laser light is delivered internally into the model through an optical fiber, is compared to dermal light administration, that is, illumination onto the skin, for the model with structure inside the lung. The internal light administration generally resulted in larger gas absorption, and higher signal-to-noise ratios, compared to the dermal light administration. The results from the phantom measurements show great promise for the internal illumination approach and a natural next step would be to investigate it further in clinical studies.

KW - 3D-print

KW - GASMAS

KW - light scattering

KW - optical phantom

KW - oxygen evaluation

KW - preterm infant

KW - TDLAS

UR - http://www.scopus.com/inward/record.url?scp=85065302630&partnerID=8YFLogxK

U2 - 10.1002/jbio.201800350

DO - 10.1002/jbio.201800350

M3 - Article

C2 - 30993871

AN - SCOPUS:85065302630

VL - 12

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 8

M1 - e201800350

ER -