Computer simulation analysis of source-detector position for percutaneously measured O2-gas signal in a three-dimensional preterm infant lung

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Computer simulation analysis of source-detector position for percutaneously measured O2-gas signal in a three-dimensional preterm infant lung. / Liao, Peilang; Larsson, Jim; Krite Svanberg, Emilie; Lundin, Patrik; Swartling, Johannes; Lewander Xu, Märta; Bood, Joakim; Andersson-Engels, Stefan.

I: Journal of Biophotonics, Vol. 11, Nr. 11, e201800023, 2018.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Liao, Peilang ; Larsson, Jim ; Krite Svanberg, Emilie ; Lundin, Patrik ; Swartling, Johannes ; Lewander Xu, Märta ; Bood, Joakim ; Andersson-Engels, Stefan. / Computer simulation analysis of source-detector position for percutaneously measured O2-gas signal in a three-dimensional preterm infant lung. I: Journal of Biophotonics. 2018 ; Vol. 11, Nr. 11.

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TY - JOUR

T1 - Computer simulation analysis of source-detector position for percutaneously measured O2-gas signal in a three-dimensional preterm infant lung

AU - Liao, Peilang

AU - Larsson, Jim

AU - Krite Svanberg, Emilie

AU - Lundin, Patrik

AU - Swartling, Johannes

AU - Lewander Xu, Märta

AU - Bood, Joakim

AU - Andersson-Engels, Stefan

PY - 2018

Y1 - 2018

N2 - Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three-dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport simulations are performed to provide information about the position dependence of the laser- and detector probe on the thorax of the infant. The result of the simulations, based on the study method and the specified model used in this work, indicates that measurement geometries in front and on the side of the lung are favorable in order to obtain a good gas absorption signal.

AB - Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three-dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport simulations are performed to provide information about the position dependence of the laser- and detector probe on the thorax of the infant. The result of the simulations, based on the study method and the specified model used in this work, indicates that measurement geometries in front and on the side of the lung are favorable in order to obtain a good gas absorption signal.

KW - Computational phantom

KW - Light transport simulation

KW - Preterm infants

KW - Respiratory distress syndrome

KW - Tunable diode laser absorption spectroscopy

U2 - 10.1002/jbio.201800023

DO - 10.1002/jbio.201800023

M3 - Article

C2 - 29978572

AN - SCOPUS:85050999982

VL - 11

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 11

M1 - e201800023

ER -