Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
Originalspråkengelska
Artikelnummer18
TidskriftEpigenetics & Chromatin
Volym6
Utgivningsnummer1
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa

Nedladdningar

Ingen tillgänglig data