Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Detaljer

Författare
  • Mireia Obón-Santacana
  • Leila Luján-Barroso
  • Heinz Freisling
  • Sabine Naudin
  • Marie Christine Boutron-Ruault
  • Francesca Romana Mancini
  • Vinciane Rebours
  • Tilman Kühn
  • Verena Katzke
  • Heiner Boeing
  • Anne Tjønneland
  • Anja Olsen
  • Kim Overvad
  • Cristina Lasheras
  • Miguel Rodríguez-Barranco
  • Pilar Amiano
  • Carmen Santiuste
  • Eva Ardanaz
  • Kay Thee Khaw
  • Nicholas J. Wareham
  • Julie A. Schmidt
  • Dagfinn Aune
  • Antonia Trichopoulou
  • Paschalis Thriskos
  • Eleni Peppa
  • Giovanna Masala
  • Sara Grioni
  • Rosario Tumino
  • Salvatore Panico
  • Bas Bueno-de-Mesquita
  • Veronica Sciannameo
  • Roel Vermeulen
  • Malin Sund
  • Elisabete Weiderpass
  • Guri Skeie
  • Carlos A. González
  • Elio Riboli
  • Eric J. Duell
Enheter & grupper
Externa organisationer
  • Bellvitge University Hospital-IDIBELL
  • University of Barcelona
  • International Agency for Research on Cancer, World Health Organization
  • University of Paris-Sud
  • Paris Diderot University
  • German Cancer Research Centre
  • German Institute of Human Nutrition
  • Danish Cancer Society Research Center
  • University of Copenhagen
  • Aarhus University
  • University of Oviedo
  • University of Granada
  • Instituto BIO-Donostia
  • Murcia Regional Health Council
  • Health Research Institute of Navarra (IDISNA)
  • CIBER Epidemiology and Public Health (CIBERESP)
  • University of Cambridge
  • University of Oxford
  • Imperial College London
  • Bjørknes University College
  • Oslo university hospital
  • Hellenic Health Foundation, Athens
  • Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
  • Istituto Nazionale dei Tumori
  • Civic and M.P.Arezzo Hospital
  • University of Naples Federico II
  • National Institute for Public Health and the Environment (RIVM)
  • University Medical Center Utrecht
  • University of Malaya
  • Umeå University
  • UiT The Arctic University of Norway, Tromsø
  • L'Hospitalet de Llobregat, Barcelona
  • Institut Gustave Roussy
  • Beaujon Hospital
  • Navarre Public Health Institute (ISPN)
  • Azienda Sanitaria Locale Torino 3
  • Utrecht University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Näringslära

Nyckelord

Originalspråkengelska
Sidor (från-till)76-84
TidskriftInternational Journal of Cancer
Volym146
Utgåva nummer1
Tidigt onlinedatum2019 maj 20
StatusPublished - 2020
PublikationskategoriForskning
Peer review utfördJa