Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol

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Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol. / Hagvall, Lina; Bruze, Magnus; Engfeldt, Malin; Isaksson, Marléne; Lindberg, Magnus; Ryberg, Kristina; Stenberg, Berndt; Svedman, Cecilia; Karlberg, Ann Therese; Bråred-Christensson, Johanna.

I: Contact Dermatitis, Vol. 82, Nr. 1, 2020, s. 31-38.

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Hagvall, Lina ; Bruze, Magnus ; Engfeldt, Malin ; Isaksson, Marléne ; Lindberg, Magnus ; Ryberg, Kristina ; Stenberg, Berndt ; Svedman, Cecilia ; Karlberg, Ann Therese ; Bråred-Christensson, Johanna. / Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol. I: Contact Dermatitis. 2020 ; Vol. 82, Nr. 1. s. 31-38.

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TY - JOUR

T1 - Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol

AU - Hagvall, Lina

AU - Bruze, Magnus

AU - Engfeldt, Malin

AU - Isaksson, Marléne

AU - Lindberg, Magnus

AU - Ryberg, Kristina

AU - Stenberg, Berndt

AU - Svedman, Cecilia

AU - Karlberg, Ann Therese

AU - Bråred-Christensson, Johanna

PY - 2020

Y1 - 2020

N2 - Background: Citral is commonly used as a fragrance and flavor material and consists of the aldehydes geranial and neral. Citral is included in fragrance mix (FM) II. Geranial and neral have also been identified in autoxidation of geraniol, a fragrance compound present in FM I. Objectives: To study contact allergy to citral, geranial, and neral, and concomitant reactivity to oxidized geraniol and fragrance markers of the baseline series. Methods: A total of 1476 dermatitis patients with suspected allergic contact dermatitis were patch tested using geranial, neral, and citral, all 3.5% petrolatum (pet.) as well as geraniol 6.0% and oxidized geraniol 11% pet. in addition to the Swedish baseline series. Results: Frequencies of positive reactions to citral, geranial, and neral were 2.9%, 3.4% and 1.9%, respectively. Together, citral and geranial gave 4.2% positive patch test reactions in consecutive dermatitis patients. In patients with positive reactions to citral or its components, 25% to 34% reacted to FM II and 61% reacted to oxidized geraniol. Conclusions: Patch testing with citral, its components, or oxidized geraniol detects contact allergic reactions not detected using the baseline series. Patch testing with pure geraniol was shown to be of little value. Geranial and neral, although closely chemically related, are concluded to be separate haptens.

AB - Background: Citral is commonly used as a fragrance and flavor material and consists of the aldehydes geranial and neral. Citral is included in fragrance mix (FM) II. Geranial and neral have also been identified in autoxidation of geraniol, a fragrance compound present in FM I. Objectives: To study contact allergy to citral, geranial, and neral, and concomitant reactivity to oxidized geraniol and fragrance markers of the baseline series. Methods: A total of 1476 dermatitis patients with suspected allergic contact dermatitis were patch tested using geranial, neral, and citral, all 3.5% petrolatum (pet.) as well as geraniol 6.0% and oxidized geraniol 11% pet. in addition to the Swedish baseline series. Results: Frequencies of positive reactions to citral, geranial, and neral were 2.9%, 3.4% and 1.9%, respectively. Together, citral and geranial gave 4.2% positive patch test reactions in consecutive dermatitis patients. In patients with positive reactions to citral or its components, 25% to 34% reacted to FM II and 61% reacted to oxidized geraniol. Conclusions: Patch testing with citral, its components, or oxidized geraniol detects contact allergic reactions not detected using the baseline series. Patch testing with pure geraniol was shown to be of little value. Geranial and neral, although closely chemically related, are concluded to be separate haptens.

KW - allergic contact dermatitis

KW - autoxidation

KW - citral

KW - fragrance mix I

KW - fragrance mix II

KW - geranial

KW - geraniol

KW - neral

KW - oxidized geraniol

KW - patch testing

KW - RRID:SCR_001905

UR - http://www.scopus.com/inward/record.url?scp=85074788097&partnerID=8YFLogxK

U2 - 10.1111/cod.13404

DO - 10.1111/cod.13404

M3 - Article

VL - 82

SP - 31

EP - 38

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 1

ER -