Continuous separation of cells and particles in microfluidic systems

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Continuous separation of cells and particles in microfluidic systems. / Lenshof, Andreas; Laurell, Thomas.

I: Chemical Society Reviews, Vol. 39, Nr. 3, 2010, s. 1203-1217.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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TY - JOUR

T1 - Continuous separation of cells and particles in microfluidic systems

AU - Lenshof, Andreas

AU - Laurell, Thomas

PY - 2010

Y1 - 2010

N2 - The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references)

AB - The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references)

U2 - 10.1039/b915999c

DO - 10.1039/b915999c

M3 - Review article

VL - 39

SP - 1203

EP - 1217

JO - Chemical Society Reviews

JF - Chemical Society Reviews

SN - 0306-0012

IS - 3

ER -