Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine

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Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine. / Vagianos, Constantin; Steen, Stig; Zoucas, Evita; Asakawa, H; Jeppsson, Bengt; Bengmark, Stig.

I: Research in Experimental Medicine, Vol. 187, Nr. 5, 1987, s. 339-346.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine

AU - Vagianos, Constantin

AU - Steen, Stig

AU - Zoucas, Evita

AU - Asakawa, H

AU - Jeppsson, Bengt

AU - Bengmark, Stig

PY - 1987

Y1 - 1987

N2 - The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.

AB - The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.

KW - Cirrhosis

KW - Liver trauma

KW - Hemorrhage

KW - Norepinephrine

U2 - 10.1007/BF01855659

DO - 10.1007/BF01855659

M3 - Article

VL - 187

SP - 339

EP - 346

JO - Zeitschrift für Die Gesamte Experimentelle Medizin

JF - Zeitschrift für Die Gesamte Experimentelle Medizin

SN - 0372-8722

IS - 5

ER -