Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området
  • Klinisk medicin
  • Urologi och njurmedicin
  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)11-17
TidskriftEuropean journal of clinical microbiology & infectious diseases
Volym6
Utgivningsnummer1
StatusPublished - 1987
PublikationskategoriForskning
Peer review utfördJa