Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Probiotic bacteria provide unique opportunities to study the global responses and molecular mechanisms underlying the effects of gut-associated microorganisms in the human digestive tract. In this study, we show by comparative transcriptome analysis using DNA microarrays that the established probiotic Lactobacillus plantarum 299v specifically adapts its metabolic capacity in the human intestine for carbohydrate acquisition and expression of exopolysaccharide and protein-aceous cell surface compounds. This report constitutes the first application of global gene expression profiling of a commensal microorganism in the human gut. A core L. plantarum transcriptome expressed in the mammalian intestine was also determined through comparisons of L. plantarum 299v activities in humans to those found for L. plantarum WCFS1 in germ-free mice. These results identify the niche-specific adaptations of a dietary microorganism to the intestinal ecosystem and provide novel targets for molecular analysis of microbial-host interactions which affect human health. The ISME Journal (2010) 4, 1481-1484; doi: 10.1038/ismej.2010.61; published online 27 May 2010


  • Maria L. Marco
  • Maaike C. de Vries
  • Michiel Wels
  • Douwe Molenaar
  • Peter Mangell
  • Siv Ahrné
  • Willem M. de Vos
  • Elaine E. Vaughan
  • Michiel Kleerebezem
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kirurgi


Sidor (från-till)1481-1484
TidskriftThe Isme Journal
StatusPublished - 2010
Peer review utfördJa