Cortical and striatal circuits together encode transitions in natural behavior

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact nature of this involvement elusive. Here, we show, by analyzing spontaneous self-grooming in rats, that neuronal modulation in motor cortex and dorsal striatum is strongly related to transitions between behaviors. Our data suggest that longer action sequences in rodent grooming behavior emerge from stepwise control of individual behavioral transitions, where future actions are encoded differently depending on current motor state. This state-dependent motor coding was found to differentiate between rare behavioral transitions and as opposed to more habitual sequencing of actions.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
Originalspråkengelska
Artikelnummereabc1173
TidskriftScience Advances
Volym6
Utgåva nummer41
StatusPublished - 2020 okt 7
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Joel Sjöbom, 2021, Lund: Lund University, Faculty of Medicine. 74 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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