Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. / Haukvik, U. K.; Schaer, M.; Nesvag, R.; McNeil, Thomas; Hartberg, C. B.; Jonsson, E. G.; Eliez, S.; Agartz, I.

I: Psychological Medicine, Vol. 42, Nr. 6, 2012, s. 1329-1337.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Haukvik, UK, Schaer, M, Nesvag, R, McNeil, T, Hartberg, CB, Jonsson, EG, Eliez, S & Agartz, I 2012, 'Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls', Psychological Medicine, vol. 42, nr. 6, s. 1329-1337. https://doi.org/10.1017/S0033291711002315

APA

Haukvik, U. K., Schaer, M., Nesvag, R., McNeil, T., Hartberg, C. B., Jonsson, E. G., Eliez, S., & Agartz, I. (2012). Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. Psychological Medicine, 42(6), 1329-1337. https://doi.org/10.1017/S0033291711002315

CBE

MLA

Vancouver

Author

Haukvik, U. K. ; Schaer, M. ; Nesvag, R. ; McNeil, Thomas ; Hartberg, C. B. ; Jonsson, E. G. ; Eliez, S. ; Agartz, I. / Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. I: Psychological Medicine. 2012 ; Vol. 42, Nr. 6. s. 1329-1337.

RIS

TY - JOUR

T1 - Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls

AU - Haukvik, U. K.

AU - Schaer, M.

AU - Nesvag, R.

AU - McNeil, Thomas

AU - Hartberg, C. B.

AU - Jonsson, E. G.

AU - Eliez, S.

AU - Agartz, I.

PY - 2012

Y1 - 2012

N2 - Background. The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls. Method. In total, 54 schizophrenia patients and 54 healthy control subjects underwent clinical examination and magnetic resonance image scanning on a 1.5 T scanner. Information on OCs was collected from original birth records. An automated algorithm was used to calculate a three-dimensional local gyrification index (lGI) at numerous points across the cortical mantle. Results. In both schizophrenia patients and healthy controls, an increasing number of OCs was significantly related to lower lGI in the left pars triangularis (p<0.0005) in Broca's area. For five other anatomical cortical parcellations in the left hemisphere, a similar trend was demonstrated. No significant relationships between OCs and lGI were found in the right hemisphere and there were no significant case-control differences in lGI. Conclusions. The reduced cortical folding in the left pars triangularis, associated with OCs in both patients and control subjects suggests that the cortical effect of OCs is caused by factors shared by schizophrenia patients and healthy controls rather than factors related to schizophrenia alone.

AB - Background. The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls. Method. In total, 54 schizophrenia patients and 54 healthy control subjects underwent clinical examination and magnetic resonance image scanning on a 1.5 T scanner. Information on OCs was collected from original birth records. An automated algorithm was used to calculate a three-dimensional local gyrification index (lGI) at numerous points across the cortical mantle. Results. In both schizophrenia patients and healthy controls, an increasing number of OCs was significantly related to lower lGI in the left pars triangularis (p<0.0005) in Broca's area. For five other anatomical cortical parcellations in the left hemisphere, a similar trend was demonstrated. No significant relationships between OCs and lGI were found in the right hemisphere and there were no significant case-control differences in lGI. Conclusions. The reduced cortical folding in the left pars triangularis, associated with OCs in both patients and control subjects suggests that the cortical effect of OCs is caused by factors shared by schizophrenia patients and healthy controls rather than factors related to schizophrenia alone.

KW - Broca's area

KW - gyrification

KW - MRI

KW - neurodevelopment

KW - obstetric

KW - complications

KW - schizophrenia

U2 - 10.1017/S0033291711002315

DO - 10.1017/S0033291711002315

M3 - Article

C2 - 22029970

VL - 42

SP - 1329

EP - 1337

JO - Psychological Medicine

JF - Psychological Medicine

SN - 1469-8978

IS - 6

ER -