Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. To further elucidate the host flagellin-sensing pathway, we generated mice deficient in the intracellular sensor Naip5. These mice failed to activate the inflammasome in response to the 35 amino acids of flagellin or in response to Legionella pneumophila infection. Our data clarify the molecular basis for the cytosolic response to flagellin.

Detaljer

Författare
  • Karla L Lightfield
  • Jenny Persson
  • Sky W Brubaker
  • Chelsea E Witte
  • Jakob von Moltke
  • Eric A Dunipace
  • Thomas Henry
  • Yao-Hui Sun
  • Dragana Cado
  • William F Dietrich
  • Denise M Monack
  • Renée M Tsolis
  • Russell E Vance
Externa organisationer
  • University of California, Berkeley
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)1171-8
Antal sidor8
TidskriftNature Immunology
Volym9
Utgåva nummer10
StatusPublished - 2008 okt
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa