CSF and blood biomarkers for Parkinson's disease

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.

Detaljer

Författare
  • Lucilla Parnetti
  • Lorenzo Gaetani
  • Paolo Eusebi
  • Silvia Paciotti
  • Oskar Hansson
  • Omar El-Agnaf
  • Brit Mollenhauer
  • Kaj Blennow
  • Paolo Calabresi
Enheter & grupper
Externa organisationer
  • University of Perugia
  • Skåne University Hospital
  • University Medical Center Göttingen
  • Sahlgrenska University Hospital
  • Göteborgs universitet
  • Hamad Bin Khalifa University
  • Paracelsus-Elena-Klinik Kassel
  • IRCCS Fondazione Santa Lucia
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi
Originalspråkengelska
Sidor (från-till)573-586
Antal sidor14
TidskriftThe Lancet Neurology
Volym18
Utgivningsnummer6
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa