CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

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Abstract

Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.

Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole-brain functional magnetic resonance imaging novelty responses to scene images.

Results: Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated-tau or Aβ42 levels and novelty responses.

Discussion: Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

Detaljer

Författare
  • Emrah Düzel
  • Hartmut Schütze
  • Arturo Cardenas-Blanco
  • Coraline Metzger
  • Matthew Betts
  • Gabriel Ziegler
  • Yi Chen
  • Laura Dobisch
  • Daniel Bittner
  • Wenzel Glanz
  • Martin Reuter
  • Annika Spottke
  • Janna Rudolph
  • Frederic Brosseron
  • Katharina Buerger
  • Daniel Janowitz
  • Klaus Fliessbach
  • Michael Heneka
  • Christoph Laske
  • Martina Buchmann
  • Peter Nestor
  • Oliver Peters
  • Dominik Diesing
  • Siyao Li
  • Josef Priller
  • Eike Jakob Spruth
  • Slawek Altenstein
  • Alfredo Ramirez
  • Anja Schneider
  • Barbara Kofler
  • Oliver Speck
  • Stefan Teipel
  • Ingo Kilimann
  • Martin Dyrba
  • Jens Wiltfang
  • Claudia Bartels
  • Steffen Wolfsgruber
  • Michael Wagner
  • Frank Jessen
Externa organisationer
  • German Center for Neurodegenerative Diseases (DZNE) Magdeburg
  • Otto von Guericke University Magdeburg
  • University College London
  • Universitätsklinikum Bonn
Originalspråkengelska
Sidor (från-till)782-790
TidskriftAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volym10
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa