Cubosomes for in vivo fluorescence lifetime imaging

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection.

Detaljer

Författare
  • Stefania Biffi
  • Laura Andolfi
  • Claudia Caltagirone
  • Chiara Garrovo
  • Angela M Falchi
  • Vito Lippolis
  • Andrea Lorenzon
  • Paolo Macor
  • Valeria Meli
  • Maura Monduzzi
  • Marc Obiols-Rabasa
  • Luca Petrizza
  • Luca Prodi
  • Antonella Rosa
  • Judith Schmidt
  • Yeshayahu Talmon
  • Sergio Murgia
Enheter & grupper
Externa organisationer
  • University of Cagliari
  • Technion - Israel Institute of Technology
  • Burlo Garofolo Pediatric Institute
  • Istituto Officina dei Materiali
  • CBM Cluster in Biomedicine
  • University of Trieste
  • University of Bologna
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk bildbehandling

Nyckelord

Originalspråkengelska
Artikelnummer055102
TidskriftNanotechnology
Volym28
Utgivningsnummer5
StatusPublished - 2017 feb 3
PublikationskategoriForskning
Peer review utfördJa