Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin and orosomucoid were measured in plasma samples from 35 patients the day before elective surgery and subsequently during seven consecutive days. Results. Twenty patients had CRP-levels below 1 mg/L before surgery and low levels of the additional inflammatory markers. Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation. The cystatin C level did not change significantly during the observation period and did not correlate significantly with the level of any of the four inflammatory markers. The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period. Conclusion. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of GFR.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
  • Farmakologi och toxikologi
  • Neurologi
  • Kirurgi
  • Radiologi och bildbehandling
  • Läkemedelskemi
Originalspråkengelska
Sidor (från-till)145-149
TidskriftScandinavian Journal of Clinical and Laboratory Investigation
Volym71
StatusPublished - 2011
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Veronica Lindström, 2013, Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University. 62 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Östner, G., 2013, Division of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University. 98 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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