Cytogenetic findings in pediatric renal cell carcinoma

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.

Detaljer

Författare
  • Maria Johansson Soller
  • Carl-Magnus Kullendorff
  • Albert N Békássy
  • Jan Alumets
  • Fredrik Mertens
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Pediatrik
  • Medicinsk genetik

Nyckelord

Originalspråkengelska
Sidor (från-till)75-80
Antal sidor6
TidskriftCancer Genetics and Cytogenetics
Volym173
Utgåva nummer1
StatusPublished - 2007 feb
PublikationskategoriForskning
Peer review utfördJa