Dairy product intake and risk of type 2 diabetes in EPIC-interact: A mendelian randomization study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Dairy product intake and risk of type 2 diabetes in EPIC-interact : A mendelian randomization study. / Vissers, Linda E.T.; Sluijs, Ivonne; van der Schouw, Yvonne T.; Forouhi, Nita G.; Imamura, Fumiaki; Burgess, Stephen; Barricarte, Aurelio; Boeing, Heiner; Bonet, Catalina; Chirlaque, Maria Dolores; Fagherazzi, Guy; Franks, Paul W.; Freisling, Heinz; Gunter, Marc J.; Ramón Quirós, J.; Ibsen, Daniel B.; Kaaks, Rudolf; Key, Timothy; Khaw, Kay T.; Kühn, Tilman; Mokoroa, Olatz; Nilsson, Peter M.; Overvad, Kim; Pala, Valeria; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Spijkerman, Annemieke M.W.; Tjonneland, Anne; Tumino, Rosario; Rodríguez-Barranco, Miguel; Rolandsson, Olov; Riboli, Elio; Sharp, Stephen J.; Langenberg, Claudia; Wareham, Nicholas J.

I: Diabetes Care, Vol. 42, Nr. 4, 2019, s. 568-575.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Vissers, LET, Sluijs, I, van der Schouw, YT, Forouhi, NG, Imamura, F, Burgess, S, Barricarte, A, Boeing, H, Bonet, C, Chirlaque, MD, Fagherazzi, G, Franks, PW, Freisling, H, Gunter, MJ, Ramón Quirós, J, Ibsen, DB, Kaaks, R, Key, T, Khaw, KT, Kühn, T, Mokoroa, O, Nilsson, PM, Overvad, K, Pala, V, Palli, D, Panico, S, Sacerdote, C, Spijkerman, AMW, Tjonneland, A, Tumino, R, Rodríguez-Barranco, M, Rolandsson, O, Riboli, E, Sharp, SJ, Langenberg, C & Wareham, NJ 2019, 'Dairy product intake and risk of type 2 diabetes in EPIC-interact: A mendelian randomization study', Diabetes Care, vol. 42, nr. 4, s. 568-575. https://doi.org/10.2337/dc18-2034

APA

Vissers, L. E. T., Sluijs, I., van der Schouw, Y. T., Forouhi, N. G., Imamura, F., Burgess, S., ... Wareham, N. J. (2019). Dairy product intake and risk of type 2 diabetes in EPIC-interact: A mendelian randomization study. Diabetes Care, 42(4), 568-575. https://doi.org/10.2337/dc18-2034

CBE

Vissers LET, Sluijs I, van der Schouw YT, Forouhi NG, Imamura F, Burgess S, Barricarte A, Boeing H, Bonet C, Chirlaque MD, Fagherazzi G, Franks PW, Freisling H, Gunter MJ, Ramón Quirós J, Ibsen DB, Kaaks R, Key T, Khaw KT, Kühn T, Mokoroa O, Nilsson PM, Overvad K, Pala V, Palli D, Panico S, Sacerdote C, Spijkerman AMW, Tjonneland A, Tumino R, Rodríguez-Barranco M, Rolandsson O, Riboli E, Sharp SJ, Langenberg C, Wareham NJ. 2019. Dairy product intake and risk of type 2 diabetes in EPIC-interact: A mendelian randomization study. Diabetes Care. 42(4):568-575. https://doi.org/10.2337/dc18-2034

MLA

Vancouver

Vissers LET, Sluijs I, van der Schouw YT, Forouhi NG, Imamura F, Burgess S et al. Dairy product intake and risk of type 2 diabetes in EPIC-interact: A mendelian randomization study. Diabetes Care. 2019;42(4):568-575. https://doi.org/10.2337/dc18-2034

Author

Vissers, Linda E.T. ; Sluijs, Ivonne ; van der Schouw, Yvonne T. ; Forouhi, Nita G. ; Imamura, Fumiaki ; Burgess, Stephen ; Barricarte, Aurelio ; Boeing, Heiner ; Bonet, Catalina ; Chirlaque, Maria Dolores ; Fagherazzi, Guy ; Franks, Paul W. ; Freisling, Heinz ; Gunter, Marc J. ; Ramón Quirós, J. ; Ibsen, Daniel B. ; Kaaks, Rudolf ; Key, Timothy ; Khaw, Kay T. ; Kühn, Tilman ; Mokoroa, Olatz ; Nilsson, Peter M. ; Overvad, Kim ; Pala, Valeria ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Spijkerman, Annemieke M.W. ; Tjonneland, Anne ; Tumino, Rosario ; Rodríguez-Barranco, Miguel ; Rolandsson, Olov ; Riboli, Elio ; Sharp, Stephen J. ; Langenberg, Claudia ; Wareham, Nicholas J. / Dairy product intake and risk of type 2 diabetes in EPIC-interact : A mendelian randomization study. I: Diabetes Care. 2019 ; Vol. 42, Nr. 4. s. 568-575.

RIS

TY - JOUR

T1 - Dairy product intake and risk of type 2 diabetes in EPIC-interact

T2 - Diabetes Reviews

AU - Vissers, Linda E.T.

AU - Sluijs, Ivonne

AU - van der Schouw, Yvonne T.

AU - Forouhi, Nita G.

AU - Imamura, Fumiaki

AU - Burgess, Stephen

AU - Barricarte, Aurelio

AU - Boeing, Heiner

AU - Bonet, Catalina

AU - Chirlaque, Maria Dolores

AU - Fagherazzi, Guy

AU - Franks, Paul W.

AU - Freisling, Heinz

AU - Gunter, Marc J.

AU - Ramón Quirós, J.

AU - Ibsen, Daniel B.

AU - Kaaks, Rudolf

AU - Key, Timothy

AU - Khaw, Kay T.

AU - Kühn, Tilman

AU - Mokoroa, Olatz

AU - Nilsson, Peter M.

AU - Overvad, Kim

AU - Pala, Valeria

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Spijkerman, Annemieke M.W.

AU - Tjonneland, Anne

AU - Tumino, Rosario

AU - Rodríguez-Barranco, Miguel

AU - Rolandsson, Olov

AU - Riboli, Elio

AU - Sharp, Stephen J.

AU - Langenberg, Claudia

AU - Wareham, Nicholas J.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (b 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (b 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (b 27.0 g/day, 95% CI 212.4 to 21.7 per additional LP allele), nonalcoholic beverages (b 218.0 g/day, 95% CI 234.4 to 21.6), and wine (b 24.8 g/day, 95% CI 29.1 to 20.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio per 15 g/day 0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.

AB - OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (b 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (b 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (b 27.0 g/day, 95% CI 212.4 to 21.7 per additional LP allele), nonalcoholic beverages (b 218.0 g/day, 95% CI 234.4 to 21.6), and wine (b 24.8 g/day, 95% CI 29.1 to 20.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio per 15 g/day 0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.

U2 - 10.2337/dc18-2034

DO - 10.2337/dc18-2034

M3 - Article

VL - 42

SP - 568

EP - 575

JO - Diabetes Reviews

JF - Diabetes Reviews

SN - 1935-5548

IS - 4

ER -