Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Detaljer

Författare
  • Oliver Kluth
  • Mandy Stadion
  • Pascal Gottmann
  • Heja Aga
  • Markus Jähnert
  • Stephan Scherneck
  • Heike Vogel
  • Ulrika Krus
  • Anett Seelig
  • Charlotte Ling
  • Jantje Gerdes
  • Annette Schürmann
Enheter & grupper
Externa organisationer
  • German Institute of Human Nutrition
  • Technical University of Braunschweig
  • Helmholtz Zentrum München
  • University of Potsdam
  • German Center for Diabetes Research
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
  • Endokrinologi och diabetes

Nyckelord

Originalspråkengelska
Sidor (från-till)3027-3036.e3
TidskriftCell Reports
Volym26
Utgivningsnummer11
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa