Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.

Detaljer

Författare
  • Wassilios G. Meissner
  • Daniel Harnack
  • Gesine Paul
  • Torsten Reum
  • Reinhard Sohr
  • Rudolf Morgenstern
  • Andreas Kupsch
Externa organisationer
  • Humboldt University of Berlin
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)105-8
Antal sidor4
TidskriftNeuroscience Letters
Volym328
Utgåva nummer2
StatusPublished - 2002 aug 9
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa