Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats

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Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats. / Meissner, Wassilios G.; Harnack, Daniel; Paul, Gesine; Reum, Torsten; Sohr, Reinhard; Morgenstern, Rudolf; Kupsch, Andreas.

I: Neuroscience Letters, Vol. 328, Nr. 2, 09.08.2002, s. 105-8.

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Meissner, Wassilios G. ; Harnack, Daniel ; Paul, Gesine ; Reum, Torsten ; Sohr, Reinhard ; Morgenstern, Rudolf ; Kupsch, Andreas. / Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats. I: Neuroscience Letters. 2002 ; Vol. 328, Nr. 2. s. 105-8.

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TY - JOUR

T1 - Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats

AU - Meissner, Wassilios G.

AU - Harnack, Daniel

AU - Paul, Gesine

AU - Reum, Torsten

AU - Sohr, Reinhard

AU - Morgenstern, Rudolf

AU - Kupsch, Andreas

PY - 2002/8/9

Y1 - 2002/8/9

N2 - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.

AB - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are still unknown. In an attempt to elucidate those mechanisms, we have previously demonstrated that STN-DBS increases striatal extracellular dopamine (DA) metabolites in anaesthetized rats. PD being a movement disorder, it remains to be determined whether these findings are related to any relevant motor or behavioural changes. Thus, this study investigates concomitant behavioural changes during STN-DBS and extracellular striatal DA metabolites measured using microdialysis in freely moving 6-hydroxydopamine-lesioned rats. STN-DBS induced an increase of striatal DA metabolites in awake, freely moving animals. Furthermore, we observed concomitant contralateral circling behaviour. Taken together, these results suggest that STN-DBS could disinhibit (consequently activate) substantia nigra compacta neurons via inhibition of gamma-aminobutyric acid-ergic substantia nigra reticulata neurons.

KW - 3,4-Dihydroxyphenylacetic Acid

KW - Animals

KW - Cell Death

KW - Disease Models, Animal

KW - Dopamine

KW - Electric Stimulation Therapy

KW - Functional Laterality

KW - Male

KW - Neostriatum

KW - Neural Pathways

KW - Oxidopamine

KW - Parkinsonian Disorders

KW - Rats

KW - Rats, Wistar

KW - Rotation

KW - Substantia Nigra

KW - Subthalamic Nucleus

KW - Sympatholytics

KW - Tyrosine 3-Monooxygenase

KW - Up-Regulation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 12133566

VL - 328

SP - 105

EP - 108

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -