Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants.

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Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants. / Giebel, Clarissa M; Sutcliffe, Caroline; Renom-Guiteras, Anna; Arve, Seija; Rahm Hallberg, Ingalill; Soto, Maria; Zabalegui, Adelaida; Hamers, Jan; Saks, Kai; Challis, David.

I: International Psychogeriatrics, Vol. 27, Nr. 4, 2015, s. 657-667.

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Giebel, Clarissa M ; Sutcliffe, Caroline ; Renom-Guiteras, Anna ; Arve, Seija ; Rahm Hallberg, Ingalill ; Soto, Maria ; Zabalegui, Adelaida ; Hamers, Jan ; Saks, Kai ; Challis, David. / Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants. I: International Psychogeriatrics. 2015 ; Vol. 27, Nr. 4. s. 657-667.

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TY - JOUR

T1 - Depressive symptomatology in severe dementia in a European sample: prevalence, associated factors and prescription rate of antidepressants.

AU - Giebel, Clarissa M

AU - Sutcliffe, Caroline

AU - Renom-Guiteras, Anna

AU - Arve, Seija

AU - Rahm Hallberg, Ingalill

AU - Soto, Maria

AU - Zabalegui, Adelaida

AU - Hamers, Jan

AU - Saks, Kai

AU - Challis, David

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: The Vårdal Institute (016540000)

PY - 2015

Y1 - 2015

N2 - ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy measures of activities of daily living (ADLs), depression, neuropsychiatric symptoms, QoL and comorbidity. Results: Findings indicated that 30% of the sample had depression, whilst the highest and lowest prevalence of depression was reported in Germany and Finland, respectively. Lower QoL, the presence of pain and more frequent neuropsychiatric symptoms were associated with depressive symptomatology, whilst no significant relationship between impairment of ADLs, comorbidity, and depression emerged. Spain and Estonia had the highest and lowest rates of antidepressant prescribing, respectively, whilst Germany had the highest discrepancy between depressive symptomatology and prescription. Conclusions: The study highlights variations across countries in the prevalence of depressive symptomatology in severe dementia and prescription of antidepressants. Information about factors associated with depressive symptomatology may help to better identify and manage depression.

AB - ABSTRACT Background: Depression is a common comorbid disorder of dementia. This study explores the prevalence of and factors associated with depressive symptomatology, and antidepressant prescription rates in severe dementia across eight European countries. Methods: In total, 414 people with severe dementia completed measures of cognition and quality of life (QoL), whilst carers completed proxy measures of activities of daily living (ADLs), depression, neuropsychiatric symptoms, QoL and comorbidity. Results: Findings indicated that 30% of the sample had depression, whilst the highest and lowest prevalence of depression was reported in Germany and Finland, respectively. Lower QoL, the presence of pain and more frequent neuropsychiatric symptoms were associated with depressive symptomatology, whilst no significant relationship between impairment of ADLs, comorbidity, and depression emerged. Spain and Estonia had the highest and lowest rates of antidepressant prescribing, respectively, whilst Germany had the highest discrepancy between depressive symptomatology and prescription. Conclusions: The study highlights variations across countries in the prevalence of depressive symptomatology in severe dementia and prescription of antidepressants. Information about factors associated with depressive symptomatology may help to better identify and manage depression.

U2 - 10.1017/S1041610214002610

DO - 10.1017/S1041610214002610

M3 - Article

VL - 27

SP - 657

EP - 667

JO - International Psychogeriatrics

JF - International Psychogeriatrics

SN - 1741-203X

IS - 4

ER -