Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


title = "Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.",
abstract = "The Wnt signaling pathway is frequently deranged in colorectal cancer and is a key target for future preventive and therapeutic approaches. Colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations. We characterized expression of the Wnt signaling pathway markers β-catenin, E-cadherin, TCF-4, and PTEN using immunohistochemical staining in colorectal cancers from individuals with HNPCC. Reduced membranous staining for β-catenin was found in 64% and for E-cadherin in 80% with strong correlation between these markers (P = 0.001). Nuclear β-catenin staining was detected in 19% of the tumors. Overexpression of TCF-4, which is activated by β-catenin, was found in 89% and downregulation of PTEN, which suppresses nuclear accumulation of β-catenin, was present in 54% of the tumors. In summary, altered expression of target molecules in the Wnt signaling pathway was demonstrated in the vast majority of the HNPCC-associated tumors, which support deranged Wnt-signaling as a central tumorigenic mechanism also in MMR defective colorectal cancer.",
author = "{Isinger Ekstrand}, Anna and Christina Therkildsen and Inge Bernstein and Mef Nilbert",
year = "2011",
doi = "10.1007/s10689-010-9406-x",
language = "English",
volume = "10",
pages = "239--243",
journal = "Familial Cancer",
issn = "1389-9600",
publisher = "Kluwer",