Deregulation of protein phosphatase expression in acute myeloid leukemia

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Deregulation of protein phosphatase expression in acute myeloid leukemia. / Kabir, Nuzhat N.; Rönnstrand, Lars; Kazi, Julhash U.

I: Medical Oncology, Vol. 30, Nr. 2, 2013.

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T1 - Deregulation of protein phosphatase expression in acute myeloid leukemia

AU - Kabir, Nuzhat N.

AU - Rönnstrand, Lars

AU - Kazi, Julhash U.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)

PY - 2013

Y1 - 2013

N2 - Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.

AB - Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.

KW - Dual specificity

KW - Protein serine/threonine phosphatase

KW - phosphatase

KW - Protein tyrosine

KW - Protein phosphatase

KW - Acute myeloid leukemia

KW - AML

U2 - 10.1007/s12032-013-0517-8

DO - 10.1007/s12032-013-0517-8

M3 - Article

VL - 30

JO - Medical Oncology and Tumor Pharmacotherapy

T2 - Medical Oncology and Tumor Pharmacotherapy

JF - Medical Oncology and Tumor Pharmacotherapy

SN - 0736-0118

IS - 2

ER -