Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify specific 1q21-24 target regions and genes.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Artikelnummere67222
TidskriftPLoS ONE
Volym8
Utgivningsnummer6
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa

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Relaterad forskningsoutput

Pontus Eriksson, 2018, Lund: Lund University, Faculty of Medicine. 104 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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