Detection of Bax Microsatellite Mutations and BaxΔ2 Isoform in Human Buccal Cells

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of BaxΔ2 proteins in human buccal cells. Our study provides a sensitive and non-invasive approach and a potential clinical application in diagnosis and treatment of MSI colon cancer patients.

Detaljer

Författare
  • Honghong Zhang
  • Cecilie Tassone
  • Nora Lin
  • Adriana Mañas
  • Yu Zhao
  • Jialing Xiang
Externa organisationer
  • Illinois Institute of Technology
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Artikelnummer002
TidskriftJournal of cell science & therapy
Volym6
Utgåva nummerSuppl 8
StatusPublished - 2015 sep
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa