Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach

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Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach. / Staaf, Johan; Jönsson, Mats; Karlsson, Anna F.

Methods in Molecular Biology. Vol. 2279 Humana Press, 2021. s. 91-107 (Methods in Molecular Biology; Vol. 2279).

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TY - CHAP

T1 - Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach

AU - Staaf, Johan

AU - Jönsson, Mats

AU - Karlsson, Anna F.

PY - 2021

Y1 - 2021

N2 - In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.

AB - In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.

KW - Fusion gene

KW - Gene expression

KW - NanoString

KW - Non-small cell lung carcinoma

U2 - 10.1007/978-1-0716-1278-1_8

DO - 10.1007/978-1-0716-1278-1_8

M3 - Book chapter

C2 - 33683688

AN - SCOPUS:85102521608

SN - 978-1-0716-1278-1

VL - 2279

T3 - Methods in Molecular Biology

SP - 91

EP - 107

BT - Methods in Molecular Biology

PB - Humana Press

ER -