Development and evaluation of optical techniques for tumour detection

Forskningsoutput: AvhandlingLicentiatavhandling


Different optical methods for tumour detection have been studied.
Interference between photon density waves has been examined with the aim of investigating the potential of this technique for optical transillumination diagnostics. Simulations and experiments have been performed in the time domain on realistic tissue phantoms containing bodies with differing optical properties. The recorded data were
Fourier transformed and interference reconstructed. The results suggest that this is a sensitive method for detecting inhomogeneities in turbid media such as tissue. In addition, time-resolved white-light measurements were performed in vivo and in vitro
on female breast tissue to determine its optical properties.
Fluorescence spectroscopy has been performed in vivo in the colon of 43 patients during a collaboration with Karolinska Hospital in Stockholm. Twenty-two of the patients were given ALA as a photosensitiser prior to the investigation. It was shown that adenomatous tissue can be distinguished from healthy tissue when using 337 nm excitation or when the patients had been given ALA and 405 or 436 nm excitation was used.


  • Charlotta Lindquist
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Atom- och molekylfysik och optik
Tilldelande institution
Handledare/Biträdande handledare
  • [unknown], [unknown], handledare, Extern person
StatusPublished - 1997