Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations

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Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations. / Larsson, Jim; Liao, Peilang; Lundin, Patrik; Krite Svanberg, Emilie; Swartling, Johannes; Lewander Xu, Märta; Bood, Joakim; Andersson-Engels, Stefan.

I: Journal of Biophotonics, Vol. 11, Nr. 3, e201700097, 01.03.2018.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Larsson, Jim ; Liao, Peilang ; Lundin, Patrik ; Krite Svanberg, Emilie ; Swartling, Johannes ; Lewander Xu, Märta ; Bood, Joakim ; Andersson-Engels, Stefan. / Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations. I: Journal of Biophotonics. 2018 ; Vol. 11, Nr. 3.

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TY - JOUR

T1 - Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations

AU - Larsson, Jim

AU - Liao, Peilang

AU - Lundin, Patrik

AU - Krite Svanberg, Emilie

AU - Swartling, Johannes

AU - Lewander Xu, Märta

AU - Bood, Joakim

AU - Andersson-Engels, Stefan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source–detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.

AB - There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source–detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.

KW - premature infants

KW - respiratory distress syndrome

KW - tissue phantom

KW - tunable diode laser absorption spectroscopy

U2 - 10.1002/jbio.201700097

DO - 10.1002/jbio.201700097

M3 - Article

VL - 11

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 3

M1 - e201700097

ER -