Development of Curative Therapies for Ewing Sarcomas by Interdisciplinary Cooperative Groups in Europe.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

Detaljer

Författare
  • T Bölling
  • G Braun-Munzinger
  • S Burdach
  • G Calaminus
  • A Craft
  • O Delattre
  • M-C L Deley
  • U Dirksen
  • B Dockhorn-Dworniczak
  • J Dunst
  • S Engel
  • A Faldum
  • B Fröhlich
  • H Gadner
  • U Göbel
  • G Gosheger
  • J Hardes
  • D S Hawkins
  • C Hoffmann
  • H Kovar
  • J Kruseova
  • R Ladenstein
  • I Leuschner
  • I J Lewis
  • O Oberlin
  • M Paulussen
  • J Potratz
  • A Ranft
  • C Rössig
  • C Rübe
  • R Sauer
  • O Schober
  • A Schuck
  • B Timmermann
  • F Tirode
  • H van den Berg
  • F van Valen
  • V Vieth
  • N Willich
  • W Winkelmann
  • J Whelan
  • R B Womer
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Pediatrik
Originalspråkengelska
Sidor (från-till)108-115
TidskriftKlinische Pädiatrie
Volym227
Utgivningsnummer3
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa