Development of human protein reference database as an initial platform for approaching systems biology in humans

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title = "Development of human protein reference database as an initial platform for approaching systems biology in humans",
abstract = "Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by using open source technologies and will be freely available at to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.",
keywords = "BRCA1 Protein, Computational Biology, Databases, Protein, Genetics, Medical, Humans, Macromolecular Substances, Protein Interaction Mapping, Protein Processing, Post-Translational, Protein Structure, Quaternary, Protein Structure, Tertiary, Substrate Specificity, Journal Article",
author = "Suraj Peri and Navarro, {J Daniel} and Ramars Amanchy and Kristiansen, {Troels Z} and Jonnalagadda, {Chandra Kiran} and Vineeth Surendranath and Vidya Niranjan and Babylakshmi Muthusamy and Gandhi, {T K B} and Mads Gronborg and Nieves Ibarrola and Nandan Deshpande and K Shanker and Shivashankar, {H N} and B.P. Rashmi and Ramya, {M A} and Zhixing Zhao and Chandrika, {K N} and N Padma and Harsha, {H C} and Yatish, {A J} and Kavitha, {M P} and Minal Menezes and Choudhury, {Dipanwita Roy} and Shubha Suresh and Neelanjana Ghosh and R Saravana and Sreenath Chandran and Subhalakshmi Krishna and Mary Joy and Anand, {Sanjeev K} and V Madavan and Ansamma Joseph and Wong, {Guang W} and Schiemann, {William P} and Constantinescu, {Stefan N.} and Lily Huang and Roya Khosravi-Far and Hanno Steen and Muneesh Tewari and Saghi Ghaffari and Blobe, {Gerard C} and Dang, {Chi V} and Garcia, {Joe G N} and Jonathan Pevsner and Jensen, {Ole N} and Peter Roepstorff and Deshpande, {Krishna S} and Chinnaiyan, {Arul M.} and Ada Hamosh and Aravinda Chakravarti and Akhilesh Pandey",
year = "2003",
month = "10",
doi = "10.1101/gr.1680803",
language = "English",
volume = "13",
pages = "2363--71",
journal = "Genome Research",
issn = "1549-5469",
publisher = "Cold Spring Harbor Laboratory Press",
number = "10",