Development of supersensitivity to methacholine in the rat detrusor following either parasympathetic denervation or decentralization

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Abstract

The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are in agreement with Cannon's "law of denervation". The results are discussed in relation to possible mechanisms behind the phenomenon of supersensitivity.

Detaljer

Författare
  • J Ekström
  • Lars Malmberg
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Urologi och njurmedicin
Originalspråkengelska
Sidor (från-till)175-179
TidskriftActa Physiologica Scandinavica
Volym122
Utgåva nummer2
StatusPublished - 1984
PublikationskategoriForskning
Peer review utfördJa