Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.


  • Jin Young Park
  • H. Bas Bueno-de-Mesquita
  • Pietro Ferrari
  • Elisabete Weiderpass
  • Jordi de Batlle
  • Anne Tjønneland
  • Cecilie Kyro
  • Vinciane Rebours
  • Marie Christine Boutron-Ruault
  • Francesca Romana Mancini
  • Verena Katzke
  • Tilman Kühn
  • Heiner Boeing
  • Antonia Trichopoulou
  • Carlo La Vecchia
  • Maria Kritikou
  • Giovanna Masala
  • Valeria Pala
  • Rosario Tumino
  • Salvatore Panico
  • Petra H. Peeters
  • Guri Skeie
  • Susana Merino
  • Eric J. Duell
  • Miguel Rodríguez-Barranco
  • Miren Dorronsoro
  • Maria Dolores Chirlaque
  • Eva Ardanaz
  • Björn Gylling
  • Jörn Schneede
  • Kay Tee Khaw
  • Kathryn E. Bradbury
  • Inge Huybrechts
  • Dagfinn Aune
  • Paolo Vineis
  • Nadia Slimani
Enheter & grupper
Externa organisationer
  • International Agency for Research on Cancer, World Health Organization
  • National Institute for Public Health and the Environment (RIVM)
  • University Medical Center Utrecht
  • Imperial College London
  • UiT The Arctic University of Norway, Tromsø
  • Cancer Registry of Norway Institute of Population-Based Cancer Research
  • Karolinska Institute
  • Folkhälsans forskningscentrum
  • CIBER Enfermedades Respiratorias (CIBERES)
  • Danish Cancer Society Research Center
  • Beaujon Hospital
  • Paris Diderot University
  • University of Paris-Sud
  • Stabilite genetique et oncogenese
  • German Cancer Research Centre
  • German Institute of Human Nutrition
  • Hellenic Health Foundation, Athens
  • University of Milan
  • Istituto Nazionale dei Tumori
  • University of Naples Federico II
  • Bellvitge University Hospital-IDIBELL
  • University of Granada
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Murcia Regional Health Council
  • University of Murcia
  • Health Research Institute of Navarra (IDISNA)
  • Umeå University
  • University of Cambridge
  • University of Oxford
  • Bjørknes University College

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära


Sidor (från-till)1511-1521
TidskriftInternational Journal of Cancer
Utgåva nummer7
Tidigt onlinedatum2018
StatusPublished - 2019
Peer review utfördJa