Dietary Intake of Vitamin D and Calcium and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

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Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and 1.02 (0.901.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.801.19) and 0.90 (0.791.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.


  • Sascha Abbas
  • Jakob Linseisen
  • Sabine Rohrmann
  • Jenny Chang-Claude
  • Petra H. Peeters
  • Pierre Engel
  • Magritt Brustad
  • Eiliv Lund
  • Guri Skeie
  • Anja Olsen
  • Anne Tjonneland
  • Kim Overvad
  • Marie-Christine Boutron-Ruault
  • Francoise Clavel-Chapelon
  • Guy Fagherazzi
  • Rudolf Kaaks
  • Heiner Boeing
  • Brian Buijsse
  • George Adarakis
  • Vassilis Ouranos
  • Antonia Trichopoulou
  • Giovanna Masala
  • Vittorio Krogh
  • Amalia Mattiello
  • Rosario Tumino
  • Carlotta Sacerdote
  • Genevieve Buckland
  • Marcial Vicente Argueelles Suarez
  • Maria-Jose Sanchez
  • Maria-Dolores Chirlaque
  • Aurelio Barricarte
  • Pilar Amiano
  • Elisabet Wirfalt
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kirurgi
Sidor (från-till)178-187
TidskriftNutrition and Cancer
Utgåva nummer2
StatusPublished - 2013
Peer review utfördJa