Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. / van Nielen, Monique; Feskens, Edith J. M.; Mensink, Marco; Sluijs, Ivonne; Molina, Esther; Amiano, Pilar; Ardanaz, Eva; Balkau, Beverly; Beulens, Joline W. J.; Boeing, Heiner; Clavel-Chapelon, Francoise; Fagherazzi, Guy; Franks, Paul; Halkjaer, Jytte; Maria Huerta, Jose; Katzke, Verena; Key, Timothy J.; Khaw, Kay Tee; Krogh, Vittorio; Kuhn, Tilman; Menendez, Virginia V. M.; Nilsson, Peter; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Rolandsson, Olov; Romieu, Isabelle; Sacerdote, Carlotta; Sanchez, Maria-Jose; Schulze, Matthias B.; Spijkerman, Annemieke M. W.; Tjonneland, Anne; Tumino, Rosario; Daphne, L. van der A.; Wurtz, Anne M. L.; Zamora-Ros, Raul; Langenberg, Claudia; Sharp, Stephen J.; Forouhi, Nita G.; Riboli, Elio; Wareham, Nicholas J.

I: Diabetes Care, Vol. 37, Nr. 7, 2014, s. 1854-1862.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

van Nielen, M, Feskens, EJM, Mensink, M, Sluijs, I, Molina, E, Amiano, P, Ardanaz, E, Balkau, B, Beulens, JWJ, Boeing, H, Clavel-Chapelon, F, Fagherazzi, G, Franks, P, Halkjaer, J, Maria Huerta, J, Katzke, V, Key, TJ, Khaw, KT, Krogh, V, Kuhn, T, Menendez, VVM, Nilsson, P, Overvad, K, Palli, D, Panico, S, Rolandsson, O, Romieu, I, Sacerdote, C, Sanchez, M-J, Schulze, MB, Spijkerman, AMW, Tjonneland, A, Tumino, R, Daphne, LVDA, Wurtz, AML, Zamora-Ros, R, Langenberg, C, Sharp, SJ, Forouhi, NG, Riboli, E & Wareham, NJ 2014, 'Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study', Diabetes Care, vol. 37, nr. 7, s. 1854-1862. https://doi.org/10.2337/dc13-2627

APA

van Nielen, M., Feskens, E. J. M., Mensink, M., Sluijs, I., Molina, E., Amiano, P., ... Wareham, N. J. (2014). Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care, 37(7), 1854-1862. https://doi.org/10.2337/dc13-2627

CBE

van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P, Ardanaz E, Balkau B, Beulens JWJ, Boeing H, Clavel-Chapelon F, Fagherazzi G, Franks P, Halkjaer J, Maria Huerta J, Katzke V, Key TJ, Khaw KT, Krogh V, Kuhn T, Menendez VVM, Nilsson P, Overvad K, Palli D, Panico S, Rolandsson O, Romieu I, Sacerdote C, Sanchez M-J, Schulze MB, Spijkerman AMW, Tjonneland A, Tumino R, Daphne LVDA, Wurtz AML, Zamora-Ros R, Langenberg C, Sharp SJ, Forouhi NG, Riboli E, Wareham NJ. 2014. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care. 37(7):1854-1862. https://doi.org/10.2337/dc13-2627

MLA

Vancouver

van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P et al. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care. 2014;37(7):1854-1862. https://doi.org/10.2337/dc13-2627

Author

van Nielen, Monique ; Feskens, Edith J. M. ; Mensink, Marco ; Sluijs, Ivonne ; Molina, Esther ; Amiano, Pilar ; Ardanaz, Eva ; Balkau, Beverly ; Beulens, Joline W. J. ; Boeing, Heiner ; Clavel-Chapelon, Francoise ; Fagherazzi, Guy ; Franks, Paul ; Halkjaer, Jytte ; Maria Huerta, Jose ; Katzke, Verena ; Key, Timothy J. ; Khaw, Kay Tee ; Krogh, Vittorio ; Kuhn, Tilman ; Menendez, Virginia V. M. ; Nilsson, Peter ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Rolandsson, Olov ; Romieu, Isabelle ; Sacerdote, Carlotta ; Sanchez, Maria-Jose ; Schulze, Matthias B. ; Spijkerman, Annemieke M. W. ; Tjonneland, Anne ; Tumino, Rosario ; Daphne, L. van der A. ; Wurtz, Anne M. L. ; Zamora-Ros, Raul ; Langenberg, Claudia ; Sharp, Stephen J. ; Forouhi, Nita G. ; Riboli, Elio ; Wareham, Nicholas J. / Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. I: Diabetes Care. 2014 ; Vol. 37, Nr. 7. s. 1854-1862.

RIS

TY - JOUR

T1 - Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

AU - van Nielen, Monique

AU - Feskens, Edith J. M.

AU - Mensink, Marco

AU - Sluijs, Ivonne

AU - Molina, Esther

AU - Amiano, Pilar

AU - Ardanaz, Eva

AU - Balkau, Beverly

AU - Beulens, Joline W. J.

AU - Boeing, Heiner

AU - Clavel-Chapelon, Francoise

AU - Fagherazzi, Guy

AU - Franks, Paul

AU - Halkjaer, Jytte

AU - Maria Huerta, Jose

AU - Katzke, Verena

AU - Key, Timothy J.

AU - Khaw, Kay Tee

AU - Krogh, Vittorio

AU - Kuhn, Tilman

AU - Menendez, Virginia V. M.

AU - Nilsson, Peter

AU - Overvad, Kim

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Rolandsson, Olov

AU - Romieu, Isabelle

AU - Sacerdote, Carlotta

AU - Sanchez, Maria-Jose

AU - Schulze, Matthias B.

AU - Spijkerman, Annemieke M. W.

AU - Tjonneland, Anne

AU - Tumino, Rosario

AU - Daphne, L. van der A.

AU - Wurtz, Anne M. L.

AU - Zamora-Ros, Raul

AU - Langenberg, Claudia

AU - Sharp, Stephen J.

AU - Forouhi, Nita G.

AU - Riboli, Elio

AU - Wareham, Nicholas J.

PY - 2014

Y1 - 2014

N2 - OBJECTIVE The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from eight European countries, with an average follow-up time of 12.0 years. Pooled country-specific hazard ratios (HRs) and 95% CI of prentice-weighted Cox regression analyses were used to estimate type 2 diabetes incidence according to protein intake. RESULTS After adjustment for important diabetes risk factors and dietary factors, the incidence of type 2 diabetes was higher in those with high intake of total protein (per 10 g: HR 1.06 [95% CI 1.02-1.09], P-trend < 0.001) and animal protein (per 10 g: 1.05 [1.02-1.08], P-trend = 0.001). Effect modification by sex (P < 0.001) and BMI among women (P < 0.001) was observed. Compared with the overall analyses, associations were stronger in women, more specifically obese women with a BMI > 30 kg/m(2) (per 10 g animal protein: 1.19 [1.09-1.32]), and nonsignificant in men. Plant protein intake was not associated with type 2 diabetes (per 10 g: 1.04 [0.93-1.16], P-trend = 0.098). CONCLUSIONS High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults. In view of the rapidly increasing prevalence of type 2 diabetes, limiting iso-energetic diets high in dietary proteins, particularly from animal sources, should be considered.

AB - OBJECTIVE The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from eight European countries, with an average follow-up time of 12.0 years. Pooled country-specific hazard ratios (HRs) and 95% CI of prentice-weighted Cox regression analyses were used to estimate type 2 diabetes incidence according to protein intake. RESULTS After adjustment for important diabetes risk factors and dietary factors, the incidence of type 2 diabetes was higher in those with high intake of total protein (per 10 g: HR 1.06 [95% CI 1.02-1.09], P-trend < 0.001) and animal protein (per 10 g: 1.05 [1.02-1.08], P-trend = 0.001). Effect modification by sex (P < 0.001) and BMI among women (P < 0.001) was observed. Compared with the overall analyses, associations were stronger in women, more specifically obese women with a BMI > 30 kg/m(2) (per 10 g animal protein: 1.19 [1.09-1.32]), and nonsignificant in men. Plant protein intake was not associated with type 2 diabetes (per 10 g: 1.04 [0.93-1.16], P-trend = 0.098). CONCLUSIONS High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults. In view of the rapidly increasing prevalence of type 2 diabetes, limiting iso-energetic diets high in dietary proteins, particularly from animal sources, should be considered.

U2 - 10.2337/dc13-2627

DO - 10.2337/dc13-2627

M3 - Article

VL - 37

SP - 1854

EP - 1862

JO - Diabetes Reviews

T2 - Diabetes Reviews

JF - Diabetes Reviews

SN - 1935-5548

IS - 7

ER -