Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

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Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia. / Lambertsen, Kate L; Deierborg, Tomas; Gregersen, Rikke; Clausen, Bettina H; Wirenfeldt, Martin; Nielsen, Helle H; Dalmau, Ishar; Diemer, Nils H; Dagnaes-Hansen, Frederik; Johansen, Flemming F; Keating, Armand; Finsen, Bente.

I: Journal of Neuropathology and Experimental Neurology, Vol. 70, Nr. 6, 2011, s. 481-494.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Lambertsen, KL, Deierborg, T, Gregersen, R, Clausen, BH, Wirenfeldt, M, Nielsen, HH, Dalmau, I, Diemer, NH, Dagnaes-Hansen, F, Johansen, FF, Keating, A & Finsen, B 2011, 'Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.', Journal of Neuropathology and Experimental Neurology, vol. 70, nr. 6, s. 481-494. https://doi.org/10.1097/NEN.0b013e31821db3aa

APA

CBE

Lambertsen KL, Deierborg T, Gregersen R, Clausen BH, Wirenfeldt M, Nielsen HH, Dalmau I, Diemer NH, Dagnaes-Hansen F, Johansen FF, Keating A, Finsen B. 2011. Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia. Journal of Neuropathology and Experimental Neurology. 70(6):481-494. https://doi.org/10.1097/NEN.0b013e31821db3aa

MLA

Vancouver

Author

Lambertsen, Kate L ; Deierborg, Tomas ; Gregersen, Rikke ; Clausen, Bettina H ; Wirenfeldt, Martin ; Nielsen, Helle H ; Dalmau, Ishar ; Diemer, Nils H ; Dagnaes-Hansen, Frederik ; Johansen, Flemming F ; Keating, Armand ; Finsen, Bente. / Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia. I: Journal of Neuropathology and Experimental Neurology. 2011 ; Vol. 70, Nr. 6. s. 481-494.

RIS

TY - JOUR

T1 - Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

AU - Lambertsen, Kate L

AU - Deierborg, Tomas

AU - Gregersen, Rikke

AU - Clausen, Bettina H

AU - Wirenfeldt, Martin

AU - Nielsen, Helle H

AU - Dalmau, Ishar

AU - Diemer, Nils H

AU - Dagnaes-Hansen, Frederik

AU - Johansen, Flemming F

AU - Keating, Armand

AU - Finsen, Bente

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2011

Y1 - 2011

N2 - Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.

AB - Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.

U2 - 10.1097/NEN.0b013e31821db3aa

DO - 10.1097/NEN.0b013e31821db3aa

M3 - Article

VL - 70

SP - 481

EP - 494

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 6

ER -