Directed vaccination against pneumococcal disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.

Detaljer

Författare
  • Yi Li
  • Andrew Hill
  • Marie Beitelshees
  • Shuai Shao
  • Jonathan F Lovell
  • Bruce A Davidson
  • Paul R Knight
  • Anders P Hakansson
  • Blaine A Pfeifer
  • Charles H Jones
Enheter & grupper
Externa organisationer
  • University at Buffalo
  • Abcombi Biosciences Inc.
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)6898-6903
Antal sidor6
TidskriftProceedings of the National Academy of Sciences
Volym113
Utgivningsnummer25
StatusPublished - 2016 jun 21
PublikationskategoriForskning
Peer review utfördJa

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