Discerning the ancestry of European Americans in genetic association studies

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Discerning the ancestry of European Americans in genetic association studies. / Price, Alkes L.; Butler, Johannah; Patterson, Nick; Capelli, Cristian; Pascali, Vincenzo L.; Scarnicci, Francesca; Ruiz-Linares, Andres; Groop, Leif; Saetta, Angelica A.; Korkolopoulou, Penelope; Seligsohn, Uri; Waliszewska, Alicja; Schirmer, Christine; Ardlie, Kristin; Ramos, Alexis; Nemesh, James; Arbeitman, Lori; Goldstein, David B.; Reich, David; Hirschhorn, Joel N.

I: PLoS Genetics, Vol. 4, Nr. 1, e236, 2008.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Price, AL, Butler, J, Patterson, N, Capelli, C, Pascali, VL, Scarnicci, F, Ruiz-Linares, A, Groop, L, Saetta, AA, Korkolopoulou, P, Seligsohn, U, Waliszewska, A, Schirmer, C, Ardlie, K, Ramos, A, Nemesh, J, Arbeitman, L, Goldstein, DB, Reich, D & Hirschhorn, JN 2008, 'Discerning the ancestry of European Americans in genetic association studies', PLoS Genetics, vol. 4, nr. 1, e236. https://doi.org/10.1371/journal.pgen.0030236

APA

Price, A. L., Butler, J., Patterson, N., Capelli, C., Pascali, V. L., Scarnicci, F., ... Hirschhorn, J. N. (2008). Discerning the ancestry of European Americans in genetic association studies. PLoS Genetics, 4(1), [e236]. https://doi.org/10.1371/journal.pgen.0030236

CBE

Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN. 2008. Discerning the ancestry of European Americans in genetic association studies. PLoS Genetics. 4(1). https://doi.org/10.1371/journal.pgen.0030236

MLA

Vancouver

Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F et al. Discerning the ancestry of European Americans in genetic association studies. PLoS Genetics. 2008;4(1). e236. https://doi.org/10.1371/journal.pgen.0030236

Author

Price, Alkes L. ; Butler, Johannah ; Patterson, Nick ; Capelli, Cristian ; Pascali, Vincenzo L. ; Scarnicci, Francesca ; Ruiz-Linares, Andres ; Groop, Leif ; Saetta, Angelica A. ; Korkolopoulou, Penelope ; Seligsohn, Uri ; Waliszewska, Alicja ; Schirmer, Christine ; Ardlie, Kristin ; Ramos, Alexis ; Nemesh, James ; Arbeitman, Lori ; Goldstein, David B. ; Reich, David ; Hirschhorn, Joel N. / Discerning the ancestry of European Americans in genetic association studies. I: PLoS Genetics. 2008 ; Vol. 4, Nr. 1.

RIS

TY - JOUR

T1 - Discerning the ancestry of European Americans in genetic association studies

AU - Price, Alkes L.

AU - Butler, Johannah

AU - Patterson, Nick

AU - Capelli, Cristian

AU - Pascali, Vincenzo L.

AU - Scarnicci, Francesca

AU - Ruiz-Linares, Andres

AU - Groop, Leif

AU - Saetta, Angelica A.

AU - Korkolopoulou, Penelope

AU - Seligsohn, Uri

AU - Waliszewska, Alicja

AU - Schirmer, Christine

AU - Ardlie, Kristin

AU - Ramos, Alexis

AU - Nemesh, James

AU - Arbeitman, Lori

AU - Goldstein, David B.

AU - Reich, David

AU - Hirschhorn, Joel N.

PY - 2008

Y1 - 2008

N2 - European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data.

AB - European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data.

U2 - 10.1371/journal.pgen.0030236

DO - 10.1371/journal.pgen.0030236

M3 - Article

VL - 4

JO - PLoS Genetics

T2 - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7404

IS - 1

M1 - e236

ER -