Distinct DC subsets regulate adaptive Th1 and 2 responses during Trichuris muris infection

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Low- and high-dose infections with the murine large intestinal nematode Trichuris muris are associated with induction of adaptive Th1 and Th2 responses, respectively, in mesenteric lymph nodes (MLN). Classical dendritic cells (cDC) accumulate in the large intestinal mucosa and MLN upon T. muris infection, yet their role in driving adaptive responses to infection remains largely unknown. We performed low- and high-dose T. muris infections of mice deficient in defined cDC subsets to investigate their role in induction of adaptive immune responses. Mice lacking IRF4-dependent cDC failed to clear a high-dose infection and displayed impaired Th2 responses. Conversely, mice lacking IRF8-dependent cDC cleared a low-dose infection and displayed an impaired Th1 response while increased production of Th2 cytokines. Finally, mice lacking both IRF4- and IRF8-dependent cDC were able to generate a Th2 response and clear a low-dose infection. Collectively, these results suggest that IRF4- and IRF8-dependent cDC act antagonistically during T. muris infection, and demonstrate that intestinal Th2 responses can be generated towards T. muris in the absence of IRF4-dependent cDC.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Technical University of Denmark
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
  • Infektionsmedicin

Nyckelord

Originalspråkengelska
Artikelnummere12458
TidskriftParasite Immunology
Volym39
Utgivningsnummer10
StatusPublished - 2017 okt 1
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Demiri, M., 2017, Lund : Lund University, Faculty of Medicine. 69 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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