Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD.


Enheter & grupper
Externa organisationer
  • Vrije Universiteit Amsterdam
  • VU University Medical Center
  • Severance Hospital
  • King's College London
  • University College London
  • Korea Institute of Radiological & Medical Sciences (KIRAMS)
  • Karolinska Institute
  • Skåne University Hospital
  • Yonsei University
  • University of California, San Francisco

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi


Sidor (från-till)335-344
Antal sidor10
TidskriftAlzheimer's and Dementia
Utgåva nummer2
Tidigt onlinedatum2019 okt 28
StatusPublished - 2020 feb
Peer review utfördJa