Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia. / Moëll, Christian; Garwicz, Stanislaw; Westgren, Ulf; Wiebe, Thomas.

I: Pediatric Hematology & Oncology, Vol. 4, Nr. 1, 1987, s. 1-5.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

APA

CBE

MLA

Vancouver

Author

Moëll, Christian ; Garwicz, Stanislaw ; Westgren, Ulf ; Wiebe, Thomas. / Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia. I: Pediatric Hematology & Oncology. 1987 ; Vol. 4, Nr. 1. s. 1-5.

RIS

TY - JOUR

T1 - Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia

AU - Moëll, Christian

AU - Garwicz, Stanislaw

AU - Westgren, Ulf

AU - Wiebe, Thomas

PY - 1987

Y1 - 1987

N2 - Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.

AB - Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.

KW - acute lymphoblastic leukemia

KW - children

KW - growth

KW - puberty

KW - growth hormone

KW - irradiation

KW - menarche

U2 - 10.3109/08880018709141243

DO - 10.3109/08880018709141243

M3 - Article

VL - 4

SP - 1

EP - 5

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

SN - 1521-0669

IS - 1

ER -