Diversity and functions of intestinal mononuclear phagocytes

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for â €fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Technical University of Denmark
  • University of Glasgow
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)845-864
Antal sidor20
TidskriftMucosal Immunology
Volym10
Utgivningsnummer4
StatusPublished - 2017 jul 1
PublikationskategoriForskning
Peer review utfördJa