Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine

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title = "Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine",
abstract = "Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) can additionally sensitize human cancer cell lines towards the anti-cancer drug gemcitabine. We show that this property is based on the Dm-dNK ability to efficiently phosphorylate gemcitabine. The 2.2 angstrom resolution structure of DmdNK in complex with gemcitabine shows that the residues Tyr70 and Arg105 play a crucial role in the firm positioning of gemcitabine by extra interactions made by the fluoride atoms. This explains why gemcitabine is a good substrate for Dm-dNK(. (C) 2009 Elsevier Inc. All rights reserved.",
keywords = "Structure-function relationship, Salvage pathway, Cancer, Gene-therapy, Nucleoside analogs, Deoxyribonucleoside kinase",
author = "Wolfgang Knecht and Mikkelsen, {Nils Egil} and Clausen, {Anders Ranegaard} and Mette Willer and Hans Eklund and Zoran Gojkovic and Jure Piskur",
year = "2009",
doi = "10.1016/j.bbrc.2009.03.041",
language = "English",
volume = "382",
pages = "430--433",
journal = "Biochemical and Biophysical Research Communications",
issn = "1090-2104",
publisher = "Elsevier",
number = "2",