Drug costs and benefits of medical treatments in high-unmet need solid tumours in the Nordic countries

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Introduction: Regional and hospital decision-makers increasingly require analyses assessing the cost-benefit profile of new cancer drugs. This analysis evaluates the cost-benefit profile of nano albumin-bound paclitaxel (nab-paclitaxel) in pancreatic cancer, versus other drugs indicated in high-unmet need solid tumour indications in Nordic countries (Sweden, Denmark, Finland, Norway and Sweden). Methods: For a selected number of cancer dugs, approved for metastatic cancer or non-curable treatment intention patients by the European Medicine Agency (EMA) after 2000, and indicated in high-unmet need solid tumours (defined as OS in first line for trial comparator ≤12 months), a regression analysis was conducted. Overall treatment costs of cancer drugs, divided by OS and PFS months, were related to the clinical improvement offered versus trial comparator. Results: Eleven of 42 drugs (26.2%) with at least one indication in solid tumours met inclusion criteria. On average, a good (R2 = 0.5359) fit between costs per OS month and OS relative benefit versus trial comparator was observed. Nab-paclitaxel offered an OS improvement of +27% versus trial comparator (average improvement: +31%), at a cost per OS month of €1,684 (average cost: €2,247). Correlation between costs per PFS month and relative PFS benefit versus trial comparator was still observed, but the goodness of fit was lower (R2 = 0.1853) than for the OS analysis. Conclusion: Treatment costs of new cancer therapies should reflect their clinical value, consistently among different indications with comparable characteristics. Nab-paclitaxel, recently approved in pancreatic cancer, showed a similar cost per OS or PFS month ratio compared to other drugs for high-unmet need solid tumours.


  • Pia Osterlund
  • Halfdan Sorbye
  • Per Pfeiffer
  • Anders Johnsson
  • Filipe Rodrigues
  • Gianluca Furneri
Externa organisationer
  • Helsinki University Central Hospital
  • Haukeland University Hospital
  • Odense University Hospital
  • Celgene Nordics AB
  • EBMA Consulting
  • Skåne University Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
Sidor (från-till)12-22
Antal sidor11
TidskriftJournal of Cancer Policy
StatusPublished - 2016 mar 1
Peer review utfördJa
Externt publiceradJa